diff --git a/examples/natmod/deflate/Makefile b/examples/natmod/deflate/Makefile
new file mode 100644
index 000000000..86ef29b63
--- /dev/null
+++ b/examples/natmod/deflate/Makefile
@@ -0,0 +1,13 @@
+# Location of top-level MicroPython directory
+MPY_DIR = ../../..
+
+# Name of module (different to built-in uzlib so it can coexist)
+MOD = deflate_$(ARCH)
+
+# Source files (.c or .py)
+SRC = deflate.c
+
+# Architecture to build for (x86, x64, armv7m, xtensa, xtensawin)
+ARCH = x64
+
+include $(MPY_DIR)/py/dynruntime.mk
diff --git a/examples/natmod/deflate/deflate.c b/examples/natmod/deflate/deflate.c
new file mode 100644
index 000000000..fa475bd06
--- /dev/null
+++ b/examples/natmod/deflate/deflate.c
@@ -0,0 +1,70 @@
+#define MICROPY_PY_DEFLATE (1)
+#define MICROPY_PY_DEFLATE_COMPRESS (1)
+
+#include "py/dynruntime.h"
+
+#if !defined(__linux__)
+void *memcpy(void *dst, const void *src, size_t n) {
+    return mp_fun_table.memmove_(dst, src, n);
+}
+void *memset(void *s, int c, size_t n) {
+    return mp_fun_table.memset_(s, c, n);
+}
+#endif
+
+mp_obj_full_type_t deflateio_type;
+
+#include "extmod/moddeflate.c"
+
+// Re-implemented from py/stream.c, not yet available in dynruntime.h.
+mp_obj_t mp_stream_close(mp_obj_t stream) {
+    const mp_stream_p_t *stream_p = mp_get_stream(stream);
+    int error;
+    mp_uint_t res = stream_p->ioctl(stream, MP_STREAM_CLOSE, 0, &error);
+    if (res == MP_STREAM_ERROR) {
+        mp_raise_OSError(error);
+    }
+    return mp_const_none;
+}
+MP_DEFINE_CONST_FUN_OBJ_1(mp_stream_close_obj, mp_stream_close);
+
+// Re-implemented from py/stream.c, not yet available in dynruntime.h.
+STATIC mp_obj_t mp_stream___exit__(size_t n_args, const mp_obj_t *args) {
+    (void)n_args;
+    return mp_stream_close(args[0]);
+}
+MP_DEFINE_CONST_FUN_OBJ_VAR_BETWEEN(mp_stream___exit___obj, 4, 4, mp_stream___exit__);
+
+// Re-implemented from obj.c, not yet available in dynruntime.h.
+mp_obj_t mp_identity(mp_obj_t self) {
+    return self;
+}
+MP_DEFINE_CONST_FUN_OBJ_1(mp_identity_obj, mp_identity);
+
+mp_map_elem_t deflateio_locals_dict_table[7];
+STATIC MP_DEFINE_CONST_DICT(deflateio_locals_dict, deflateio_locals_dict_table);
+
+mp_obj_t mpy_init(mp_obj_fun_bc_t *self, size_t n_args, size_t n_kw, mp_obj_t *args) {
+    MP_DYNRUNTIME_INIT_ENTRY
+
+    deflateio_type.base.type = mp_fun_table.type_type;
+    deflateio_type.name = MP_QSTR_DeflateIO;
+    MP_OBJ_TYPE_SET_SLOT(&deflateio_type, make_new, &deflateio_make_new, 0);
+    MP_OBJ_TYPE_SET_SLOT(&deflateio_type, protocol, &deflateio_stream_p, 1);
+    deflateio_locals_dict_table[0] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR_read), MP_OBJ_FROM_PTR(&mp_stream_read_obj) };
+    deflateio_locals_dict_table[1] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR_readinto), MP_OBJ_FROM_PTR(&mp_stream_readinto_obj) };
+    deflateio_locals_dict_table[2] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR_readline), MP_OBJ_FROM_PTR(&mp_stream_unbuffered_readline_obj) };
+    deflateio_locals_dict_table[3] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR_write), MP_OBJ_FROM_PTR(&mp_stream_write_obj) };
+    deflateio_locals_dict_table[4] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR_close), MP_OBJ_FROM_PTR(&mp_stream_close_obj) };
+    deflateio_locals_dict_table[5] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR___enter__), MP_OBJ_FROM_PTR(&mp_identity_obj) };
+    deflateio_locals_dict_table[6] = (mp_map_elem_t){ MP_OBJ_NEW_QSTR(MP_QSTR___exit__), MP_OBJ_FROM_PTR(&mp_stream___exit___obj) };
+    MP_OBJ_TYPE_SET_SLOT(&deflateio_type, locals_dict, (void*)&deflateio_locals_dict, 2);
+
+    mp_store_global(MP_QSTR___name__, MP_OBJ_NEW_QSTR(MP_QSTR_deflate));
+    mp_store_global(MP_QSTR_DeflateIO, MP_OBJ_FROM_PTR(&deflateio_type));
+    mp_store_global(MP_QSTR_RAW, MP_OBJ_NEW_SMALL_INT(DEFLATEIO_FORMAT_RAW));
+    mp_store_global(MP_QSTR_ZLIB, MP_OBJ_NEW_SMALL_INT(DEFLATEIO_FORMAT_ZLIB));
+    mp_store_global(MP_QSTR_GZIP, MP_OBJ_NEW_SMALL_INT(DEFLATEIO_FORMAT_GZIP));
+
+    MP_DYNRUNTIME_INIT_EXIT
+}
diff --git a/tests/run-natmodtests.py b/tests/run-natmodtests.py
index ce4f94135..576402147 100755
--- a/tests/run-natmodtests.py
+++ b/tests/run-natmodtests.py
@@ -21,6 +21,7 @@ NATMOD_EXAMPLE_DIR = "../examples/natmod/"
 # Supported tests and their corresponding mpy module
 TEST_MAPPINGS = {
     "btree": "btree/btree_$(ARCH).mpy",
+    "deflate": "deflate/deflate_$(ARCH).mpy",
     "framebuf": "framebuf/framebuf_$(ARCH).mpy",
     "heapq": "heapq/heapq_$(ARCH).mpy",
     "random": "random/random_$(ARCH).mpy",
diff --git a/tools/ci.sh b/tools/ci.sh
index bbff5359a..98e78dc78 100755
--- a/tools/ci.sh
+++ b/tools/ci.sh
@@ -426,6 +426,7 @@ function ci_native_mpy_modules_build {
     make -C examples/natmod/features2 ARCH=$arch
     make -C examples/natmod/features3 ARCH=$arch
     make -C examples/natmod/btree ARCH=$arch
+    make -C examples/natmod/deflate ARCH=$arch
     make -C examples/natmod/framebuf ARCH=$arch
     make -C examples/natmod/heapq ARCH=$arch
     make -C examples/natmod/random ARCH=$arch
@@ -495,7 +496,7 @@ function ci_unix_coverage_run_mpy_merge_tests {
 
 function ci_unix_coverage_run_native_mpy_tests {
     MICROPYPATH=examples/natmod/features2 ./ports/unix/build-coverage/micropython -m features2
-    (cd tests && ./run-natmodtests.py "$@" extmod/{btree*,framebuf*,heapq*,random*,re*}.py)
+    (cd tests && ./run-natmodtests.py "$@" extmod/{btree*,deflate*,framebuf*,heapq*,random*,re*}.py)
 }
 
 function ci_unix_32bit_setup {